Manolis Kellis
Professor of CS
Studies the mechanistic basis of human disease with computational and experimental genomics, including epigenomic annotation and gene-regulatory circuitry.
Manolis Kellis's lab at MIT works on genomics & computational biology and medical imaging & healthcare AI. 28 papers since 2023, 13 at top venues, mostly Cell and Nature Communications. 6 PhD students and 2 master's students. 159 alumni. Applications close .
At a glance
- papers, 2023–2026
- 7/ year
- at T1 venues
- 46%
- PhD students
- 6
- MS students
- 2
- alumni listed
- 159
Papers by yearfrom the lab homepage, 2023–2026
- 0 papers2026 · T1 0 · collecting
- 0 papers2025 · T1 0
- 12 papers2024 · T1 6
- 16 papers2023 · T1 7
T1 venuesOtherVenues: Cell, Nature Communications, Nucleic Acids Research, Science
Research focuspaper titles that use each topic's words
- Genomics & computational biology6 papers
- mechanistic1 paper
- annotation1 paper
- Medical imaging & healthcare AI0 papers
- basis0 papers
Paper list
From the lab homepage.
202412 papers
- Nature Communications (T1)A Polygenic Score Method Boosted by Non-additive Models
- Clinical & Experimental MetastasisAntigen presenting cells in cancer immunity and mediation of immune checkpoint blockade (opens in a new tab)
- Genome BiologyCAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods (opens in a new tab)
- Science Translational MedicineGamma entrainment using audiovisual stimuli alleviates chemobrain pathology and cognitive impairment induced by chemotherapy in mice (opens in a new tab)
- Nature MedicineIntegrative multi-omics profiling in human decedents receiving pig heart xenografts (opens in a new tab)
- Nature Communications (T1)Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types (opens in a new tab)
- Nature Communications (T1)Multisensory gamma stimulation promotes glymphatic clearance of amyloid (opens in a new tab)
- Brain Behavior, and Immunity - HealthNew approaches for understanding the potential role of microbes in Alzheimer's disease (opens in a new tab)
- Biology of Sex DifferencesRelationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease (opens in a new tab)
- Cell (T1)Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD (opens in a new tab)
- Science (T1)Single-cell multi-cohort dissection of the schizophrenia transcriptome (opens in a new tab)
- Nature Communications (T1)TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression (opens in a new tab)
202316 papers
- Clinical & Experimental MetastasisDissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics (opens in a new tab)
- Cell (T1)Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion (opens in a new tab)
- Cell ReportsExercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix (opens in a new tab)
- Nucleic Acids ResearchGENCODE: reference annotation for the human and mouse genomes in 2023 (opens in a new tab)
- Cell (T1)Human microglial state dynamics in Alzheimer's disease progression (opens in a new tab)
- Science Translational MedicineLateral mammillary body neurons in mouse brain are disproportionately vulnerable in Alzheimer's disease (opens in a new tab)
- Nature GeneticsMultitissue H3K27ac profiling of GTEx samples links epigenomic variation to disease (opens in a new tab)
- Cell (T1)Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration (opens in a new tab)
- American Journal Of Human GeneticsPower of inclusion: Enhancing polygenic prediction with admixed individuals (opens in a new tab)
- Cell (T1)SARS-CoV-2 variants evolve convergent strategies to remodel the host response (opens in a new tab)
- Cell (T1)Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology (opens in a new tab)
- Nature NeuroscienceSingle-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease (opens in a new tab)
Where alumni went159 listed
Apply to MITFall 2027
MIT EECS Computer Science PhD
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